Attention Deficit Hyperactivity Disorder, or ADHD is a brain disorder characterized by hyperactivity, impulsivity and inattentiveness. It is caused by a deficiency in dopamine and an excess of glutamate. The main treatment option includes stimulants such as Ritalin (Methylphenidate), Dexedrine (Dextroamphetamine) and Adderall (Dextroamphetamine and Amphetamine). Also used are NRIs such as Strattera (Atomoxetine). Additionally Memantine and other NMDA receptor antagonist may be used to treat ADHD. Memantine is currently used off label for treatment and Dextromethorphan shows future potential. This is evidenced by the ability of DXM to reduce glutamate receptor activation through uncompetitive antagonism of NMDA receptors which can increase dopamine and may resolve symptoms of ADHD.[1]

^ Wong BY, Coulter DA, Choi DW, Prince DA (February 1988). "Dextrorphan and dextromethorphan, common antitussives, are antiepileptic and antagonize N-methyl-D-aspartate in brain slices". Neuroscience Letters 85 (2): 261–6. http://dx.doi.org/10.1016%2F0304-3940%2888%2990362-X

Created by viscosity, 07-20-2010 at 09:54 PM Last edited by viscosity, 07-21-2010 at 09:12 PM 0 Comments, 593 Views